Laboratory Services

Sjogren's Syndrome

Print this page

Updated Test Information:

Test Description
Sjogren's Syndrome
Anti-SSB/La, Anti-SSA/Ro
Test ID
General Information
The presence of both SS-A/Ro and SS-B/La antibodies are highly specific serological markers for the diagnosis and disease management of patients with Sjögren’s syndrome or lupus patients with Sjögren's overlap syndrome. SS-A/Ro antibodies can be a marker for SLE and Sjögren’s syndrome. SS-B/La antibodies are highly specific clinical markers for Sjögren’s syndrome, but a small proportion of patients can remain SS-B/La negative. Assay results should be used in conjunction with clinical findings and other serological tests.
Specimen Type
Alternate Specimen Type
Plasma (Li-Heparin, EDTA, or Citrate)
Specimen Requirements
Additional Processing Details
Caution: Serum/plasma samples are not to be repeatedly frozen and thawed, since this can cause analyte deterioration. They are to be thawed only once.
Stored at 22˚C: 8 hrs
Stored at 2-8˚C: 48 hrs
If assays are not completed within 48 hrs or the specimen is to be stored beyond 48 hrs, the serum/plasma should be frozen at or below -20˚C.
Unacceptable Specimen Conditions
Lipemic, hemolyzed or microbially contaminated samples.
Fluorescent enzyme immunoassay (FEIA)
Estimated TAT
2-5 days
Testing Schedule
Monday-Saturday, alternating days
Test Includes
CPT Code(s)
Minimum Sample Volume
1.5 mL
Pediatric Min. Volume (if applicable)
750 uL
Reference Range
  Negative Equivocal Positive
SSA/Ro <7 7-10 >10  U/ml
SSB/La  <7 7-10 >10  U/ml
Performing Lab
Incyte Diagnostics
LOINC Code(s)
33610-7, 33613-1