Renin Activity, PlasmaPrint this page
Updated Test Information:
Renin Activity, Plasma
PRA (Plasma Renin Activity)
Investigation of primary aldosteronism (eg, adrenal adenoma/carcinoma and adrenal cortical hyperplasia) and secondary aldosteronism (renovascular disease, salt depletion, potassium loading, cardiac failure with ascites, pregnancy, Bartter syndrome)
|Additional Processing Details||
1. Draw blood in a chilled syringe from a patient in a seated position; place specimenin a chilled, lavender-top
(EDTA) tube; and mix.
2. Alternatively, draw blood directly in a chilled, lavender top (EDTA) tube.
3. Immediately place EDTA tube into an ice-water bath until thoroughly cooled.
4. Refrigerate specimen during centrifugation and immediately transfer plasmato plastic vial. (If a refrigerated
centrifuge is unavailable, chill the centrifuge carriers. Centrifuge specimen for< or =5 minutes, then promptly transfer plasma.)
5. Immediately freeze plasma.
Plasma EDTA Frozen 14 days
|Unacceptable Specimen Conditions||
Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK
Angiotensin converting enzyme (ACE) inhibitors have the potential to "falsely elevate" PRA. Therefore, in a patient
treated with an ACE-inhibitor, the findings of a detectable PRA level or a low SA:PRA ratio do not exclude the
diagnosis of primary aldosteronism. In addition, a strong predictor for primary aldosteronism is a PRA level
undetectably low in a patient taking an ACE-inhibitor.
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Monday through Friday; 1 p.m.
|Minimum Sample Volume||
Mean data not standardized as to time of day or diet. Infants were supine, children sitting.
Na-depleted, upright (peripheral vein specimen)
Na-replete, upright (peripheral vein specimen)