Creatinine Clearance

Creatinine Clearance

CC

Renal function test; estimate glomerular filtration rate (GFR); evaluate renal function in small or wasted subjects; follow possible progression of renal disease; adjust dosages of medications in which renal excretion is pivotal (eg, aminoglycosides, methotrexate, cisplatin)

Serum
Urine

SST
Urine, 24 hour collection

Urine, 24 hour collection - The test request must include date and time collection started and date and time collection finished. The 24-hour urine volume is also needed for calculation of eGFR. Collect urine without using additives. If urine must be collected with a preservative for other analytes, only hydrochloric acid (14 to 47 mmol/L urine, e.g. 5 mL 10 % HCl or 5 mL 30 % HCl per liter urine) or boric acid (81 mmol/L, e.g. 5 g per liter urine) may be used.

1 mL serum (Red, Li heparin, KEDTA plasma) AND 10 mL aliquot of entire urine collection

500 uL serum AND 500 uL aliquot of entire urine collection

Separate serum from cells within 45 minutes of collection.
For 24 hour urine, instruct the patient to void at 8 AM and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (ie, 8 AM the next morning). Screw the lid on securely. Collection container must be labeled with patient's full name, date, and start/stop times for a 24-hour collection. Submit both urine and serum simultaneously. It is preferable to collect the serum at the time the urine collection is completed or when the serum is brought to the draw station. The serum should be collected within 24 hours of the start or finish of the urine collection.

Serum:
7 days at 15-25˚C
7 days at 2-8˚C
3 months at -15 to -25˚C

Urine without preservative:
2 days at 15-25˚C
6 days at 2-8˚C
6 months at -15 to -25˚C

Urine - with preservative:
3 days at 15-25˚C
8 days at 2-8˚C
3 weeks at -15 to -25˚C

Exercise may cause increased creatinine clearance. The glomerular filtration rate is substantially increased in pregnancy. Ascorbic acid, ketone bodies (acetoacetate), hydantoin, numerous cephalosporins, and glucose may influence creatinine determinations. Trimethoprim, cimetidine, quinine, quinidine, procainamide reduce creatinine excretion. Icteric samples, lipemia, and hemolysis may interfere with determination of creatinine. Since tubular secretion of creatinine is fractionally more important in progressing renal failure, the creatinine clearance overestimates GFR with high serum creatinine levels. 

Colorimetric

0-2 days

Monday-Saturday

82575

Incyte Diagnostics

2164-2