Although culture was long considered the gold standard, the PAS stain has been shown to be a sensitive method for the diagnosis of onychomycosis.
Since 1989, there have been several significant developments in the field of cytology that have rendered the category of reactive changes to clinical obsolescence. This article explains why in a laboratory, reactive changes in a Pap are identified, confirmed to be nonneoplastic, then reported as a ‘Negative’ finding, with clear distinction of the finding from ASCUS or LSIL, without the use of HPV tests.
The combined use of E-cadherin and p120ctn immunostaining on a single slide is very helpful in subclassifying certain breast carcinomas.
Cell block preparation is useful for the detection and diagnosis of many other lesions, so why not use it as a complement to the Pap test, especially for diagnostically difficult cases?
Q&A on why laboratories utilize the reporting category “Endometrial Cells Present in a Woman over 40 Years of Age” and other important information on this topic.
Hereditary nonpolyposis colorectal cancer (HNPCC) is an inherited condition from a parent and develops through changes in their mismatch repair (MMR) genes during DNA replication. This form of genetic destabilization is referred to as the microsatellite instability (MSI) pathway.