Test Directory

ROS1 for NSCLS

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Updated Test Information:

Test Description
ROS1 for NSCLS
Synonym(s)

ROS1, NSCLC, Adenocarcinoma

General Information

Probes: ROS1 (6q22)


Disease(s): ROS1, Non-small cell lung carcinoma (NSCLC)

Specimen Requirements

FNA; Formalin fixed paraffin embedded (FFPE) tissue blocks or
2 unstained slides (4-5 microns thick sections)
1 H&E slide for pathology review (required)

Additional Processing Details

Transport to the testing lab at room temp is acceptable. Do not allow sample to overheat. Use cold pack for transport, making sure cold pack is not in direct contact with specimen

Required Information

Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source.

Unacceptable Specimen Conditions

Specimen containers without two (2) patient identifiers, specimens submitted on non-positively charged slides, paraffin blocks that have been overheated or frozen, specimens without a H&E slide, slides or paraffin blocks with no tissue remaining, Samples fixed in fixative other than 10% neutral buffered formalin.

Department (code)

FISH

Methodology

Fluorescence in-Situ Hybridization (FISH)

Estimated TAT

4-7 working days from receipt

Testing Schedule

Monday-Friday

Retention

Blocks:10 years
H&E and IHC Slides: 10 years
IF Slides: 30 days

CPT Code(s)

88377x1 manual

Additional Information

Clinical Significance: ROS1 gene rearrangements are found in 1-2% of non-small cell lung carcinoma (NSCLC).