Positive in 30% of diffuse large B-cell lymphomas and in the follicular center cells of most cases of FCC lymphoma. Also marks FCCs in benign lymphoid tissue. Useful as in distinguishing the proliferation centers in CLL/SLL which are bcl2 +/bcl6 neg, from trapped germinal centers in mantle cell lymphoma, which are bcl2 neg and bcl6 pos. Also marks rosette cells around the R-S cells in NLPHD. Requires optimum fixation.
Formalin-fixed, paraffin-embedded tissue blocks (FFPE). If tissue blocks are not available, unstained slides are acceptable (please submit 1–2 slides per antibody to be tested, cuts must be 4 microns thick).
Tissue removed during a surgical procedure and placed in 10% NBF soon after removal from the patient. Appropriate tissue for requested staining.
Complete the Incyte Diagnostics requisition with the patient's demographics and relevant clinical history.
Slides or paraffin blocks with no tissue remaining. Samples fixed in fixatives other than 10% neutral buffered formalin. Paraffin blocks that have been overheated or frozen.
IHC, Ventana Ultra Stainer
12 business days from receipt
Blocks: 10 years
Slides: 10 years
*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.