Test Directory

HER2 FISH

Synonym(s):

HER-2 fluorescence in situ hybridization, HER2/Neu by FISH

Application:

HER-2 gene amplification in formalin fixed, paraffin embedded tissues, usually human breast tissue. HER-2 FISH results correlated with clinical and pathological information can be used as a prognostic tool for stage II, node positive breast.

Specimen Type:

Formalin-fixed, paraffin-embedded tissue blocks (FFPE). If tissue blocks are not available, unstained slides are acceptable (please submit 1-2 slides per antibody to be tested, cuts must be 4 microns thick).

Collection Procedure:

Tissue removed during a surgical procedure and placed in 10% NBF soon after removal from the patient. Appropriate tissue for requested staining.

Required Information:

Complete the Incyte Diagnostics requisition with the patient's demographics and relevant clinical history.

Specimen Stability:

Ambient: Indefinite as paraffin block; 6 weeks for recut slides

Unacceptable Specimen:

Slides or paraffin blocks with no tissue remaining. Samples fixed in fixatives other than 10% neutral buffered formalin. Paraffin blocks that have been overheated or frozen.

Department:

Histology

Method:

Abbott/Vysis, immunofluorescence, DNA probes

Turnaround:

12 business days from receipt

Performed:

Monday–Thursday

Retention:

Blocks:10 years
H&E and IHC Slides: 10 years
IF Slides: 30 days

CPT Code:*

88377

*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.

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