Test Directory

BCR/ABL1 t(9;22)

Synonym(s):

ABL1, CML, ALL, MPN, BCR

Application:

The presence of the t(9;22) confirms the diagnosis of chronic myelogenous leukemia (CML). The translocation is also present in subset of patients with B-lymphoblastic leukemia/lymphoma.

Specimen Collection:

Bone Marrow Aspirate: 1–2 mL sodium heparin (green top) tube. EDTA is acceptable. Peripheral Blood: 2–5 mL sodium heparin tube (green top). EDTA is acceptable.

Required Information:

Complete the Incyte Diagnostics hematology requisition with the patient's demographics and relevant clinical history. Label the specimen containers with patient's full name, second unique identifier, and specimen site/source. Please provide a copy of the patient's complete blood count (CBC) report.

Specimen Stability:

48 hours

Unacceptable Specimen:

Specimen containers without two (2) patient identifiers, specimens submitted in inappropriate collection media, frozen specimens.

Department:

FISH

Method:

Fluorescence in-Situ Hybridization (FISH)

Turnaround:

3–5 business days from receipt

Performed:

Monday–Friday

Retention:

7 days after release of final report

CPT Code:*

88374

Notes:

If Flow Cytometry studies are also being ordered, it is preferable to submit an EDTA (purple top) tube specifically for Flow Cytometry. If only one tube can be submitted, please submit one sodium heparin (green top) tube for both FISH and Flow Cytometry studies.

*The listed CPT codes are for reference use only. Final coding is based on CPT guidelines and individual circumstances.

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